(Japansk Box, Engelsk tal & Text i spel))

In Okami HD players take on the role of Amaterasu, the Japanese sun goddess who inhabits the form of a legendary white wolf Shiranui on a quest to defeat Orochi, an eight-headed demon and tyrannical monster responsible for turning the world into a ruined wasteland. Players must use Amaterasus magical abilities and the arsenal of items, attacks and Celestial Brush techniques to restore the land of Nippon to its previous glory full of life and color. Along the way, Amaterasu will be called upon to help a cast of quirky and intriguing characters and defeat a bevy of brutal enemies to rid the land of Orochis curse.