In Crash Bandicoot: Mind Over Mutant, a rejuvenated Neo Cortex is taking over the world one brain at a time! Cortex and N. Brio devise a new kind of evil: a text-messaging, do-anything device that controls both mutant and bandicoot minds. Armed with his quick wits and lightning agility, Crash must free his friends, the titans, and save the day!

Crash: Mind over Mutant is the fifteenth installment in the Crash Bandicoot video game series, the seventh game in the main franchise, and is the second title in accordance to the mutant series chronology. The games story centers on the arrival of a popular technological device (a parody of devices such as the iPhone and BlackBerry) that puts whoever uses it under the control of the devices creators Doctor Neo Cortex and Doctor Nitrus Brio, who serve as the stories primary antagonists. Crash Bandicoot - protagonist of the series and only one unaffected by the device besides his spirit ally Aku Aku - must free his friends from the control of the device and put an end to Doctor Cortexs plot.